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KMID : 0948320060060010007
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Konyang Medical Journal
2006 Volume.6 No. 1 p.7 ~ p.12
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Effects of Cations on the Contractions Induced by Electrical Field Stimulation and High-K+ in Pig Coronary Artery
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Kim Se-Hun
Chang Seok-Jong
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Abstract
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Pig coronary artery was contracted by electrical field stimulation(EFS) or high-K+. And the effects of cations on those contractions were investigated. The helical strip of isolated coronary artery was immersed in the physiological salt solution equilibrated with 100% O2 at 37oC and its isometric tension was measured. EFS was applied for 15 seconds with 3 minutes interval. In the pig coronary artery, contraction by EFS showed current-dependency, and the contraction by high-K+ showed dose-dependency. Those contractions were Ca2+-dependent. The contractions induced by EFS (0.4A) or high K+(40 mM K+) were suppressed by Mg2+, Co2+, and Mn2+. The magnitudes of suppression by Co2+, and Mn2+ were larger in the contraction induced by EFS than that induced by high K+. From the above results, it is suggested that mechanisms of contraction induced by EFS may not be same with K+-induced contraction in spite of similar characteristics of those contractions in the pig coronary artery.
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KEYWORD
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coronary artery, electrical field stimulation, K+-contraction, Cations
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